Isoket retard (isosorbide dinitrate)

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Headache.

Dizziness.

Weakness.

Nausea.

Flushing.

A drop in blood pressure that occurs when moving from a lying down or sitting position to sitting or standing, which results in dizziness and lightheadedness (postural hypotension).

Increased heart rate (tachycardia).

Decreased heart rate (bradycardia).

Allergic skin reactions.

Fainting.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The medicines for erectile dysfunction (impotence) listed below must not be used by people taking isosorbide dinitrate, because the combination can produce a severe drop in blood pressure resulting in dizziness, fainting, or even a heart attack:

sildenafil (Viagra)

tadalafil (Cialis)

vardenafil (Levitra).

If this medicine is taken in combination with other medicines that reduce blood pressure, either as a treatment for high blood pressure (antihypertensives), or as a side effect, there may be an enhanced blood pressure lowering effect. This might make some people feel dizzy. If you do feel dizzy, you should lie down until the symptoms pass. Other medicines that can reduce blood pressure include the following:

ACE inhibitors, eg enalapril, captopril

alpha blockers, eg alfuzosin, doxazosin

alprostadil

anaesthetics

angiotensin II receptor antagonists, eg losartan

certain antipsychotic medicines, eg chlorpromazine

baclofen

benzodiazepines, eg temazepam

beta-blockers, eg propranolol

calcium channel blockers, eg diltiazem, verapamil, nifedipine

clonidine

diuretics, eg furosemide

hydralazine

levodopa

MAOI antidepressants, eg phenelzine

methyldopa

minoxidil

moxisylyte

moxonidine

other nitrates, eg glyceryl trinitrate, amyl nitrate (poppers)

tricyclic antidepressants, eg amitriptyline.

Other medicines containing the same active ingredient

Angitak spray

Cedocard retard

Isosorbide dinitrate tablets are also available without a brand name, ie as the generic medicine.

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