Indomax 75 SR

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache

Dizziness

Disturbances of the gut such as indigestion, nausea, vomiting, diarrhoea or abdominal pain

Ulceration or bleeding in the stomach or intestines

Retention of water in the body tissues (fluid retention), resulting in swelling (oedema)

Rise in blood pressure

Change in heart rate or rhythm

Hair loss

Balance disorders involving the inner ear (vertigo)

Sensation of ringing, or other noise in the ears (tinnitus)

Confusion

Depression

Anxiety

Fatigue

Difficulty sleeping (insomnia)

Pins and needles sensations

Eye pain

Blurred vision

Allergy to active ingredients (hypersensitivity) such as facial flushing, skin rash, itch, narrowing of airways (bronchospasm) or swelling of lips, tongue or throat (angioedema)

Kidney, liver or blood disorders

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before taking this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Indometacin should not be taken in combination with painkilling doses of aspirin or any other oral NSAID, eg ibuprofen, as this increases the risk of side effects on the stomach and intestines. Selective inhibitors of COX-2 such as celecoxib or etoricoxib should also be avoided for the same reason.

There may be an increased risk of ulceration or bleeding from the gut if indometacin is taken with corticosteroids such as prednisolone.

There may also be an increased risk of bleeding from the gut if indometacin is taken with the following medicines:

anti-blood-clotting (anticoagulant) medicines such as warfarin

anti-platelet medicines to reduce the risk of blood clots or 'thin the blood', eg low-dose aspirin, clopidogrel, dipyridamole

SSRI antidepressants, eg fluoxetine, paroxetine, citalopram

venlafaxine.

Indometacin may enhance the effect of blood-thinning or anti-clotting medicines (anticoagulants) such as warfarin. As this may increase the risk of bleeding, people taking indometacin with an anticoagulant should be closely monitored by their doctor.

Indometacin may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines. People taking indometacin with any of these should be closely monitored by their doctor:

digoxin

lithium

methotrexate.

There may be an increased risk of side effects on the kidneys if indometacin is taken with any of the following medicines:

ACE inhibitors, eg enalapril

ciclosporin

diuretics, eg furosemide (the diuretic triamterene should not be taken with indometacin)

tacrolimus.

Indometacin may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, such as the following:

ACE inhibitors such as captopril

beta-blockers such as propranolol

diuretics such as furosemide.

The following medicines may increase the blood level of indometacin, which may increase the risk of side effects:

diflunisal (should not be taken with indometacin)

probenecid.

If indometacin is taken with the antipsychotic medicine haloperidol there may be a risk of profound drowsiness and confusion. This combination should be avoided.

Indometacin may enhance the absorption of tiludronic acid (used for Paget's disease) from the gut. If you are taking both these medicines it is recommended the doses are separated by two hours to avoid this.

Other medicines containing the same active ingredient

Indolar SR

Pardelprin MR

Slo-Indo

Indometacin capsules, modified release capsules and suppositories are also available with out a brand name, ie as the generic medicine.

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