Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Constipation

Blurred vision

Faster than normal heart beat (tachycardia)

Difficulty in passing urine (urinary retention)

Dry mouth

Drowsiness

Confusion

Shaking, usually of the hands (tremor)

Agitation

Blood disorders

A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension)

Sexual problems

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

Imipramine should not be taken with a monoamine oxidase inhibitor (MAOI) antidepressant. Treatment with imipramine should not be started until 3 weeks after stopping a MAOI. Conversely, treatment with a MAOI should not be started until 3 weeks after stopping imipramine. Imipramine should also not be taken with moclobemide. Imipramine blood levels may be increased by: Alprazolam Anti-psychotic medication such as chlorpromazine Cimetidine Disulfiram Fluoxetine Fluvoxamine Methylphenidate. and quinidine. Imipramine blood levels may be decreased by: Barbiturates and carbamazepine. Imipramine may increase the blood levels of the anti-epileptic medicines carbamazepine and phenytoin. Imipramine may decrease the blood pressure lowering effect of: Bethanidine Debrisoquine and guanethidine. There may be a sudden and marked increase in blood pressure and heart rate when imipramine is taken with medications causing vessel constriction such as phenylephrine and adrenaline. These medicines should not be taken together. There may be an increase in the risk of arrhythmias occurring when imipramine is taken with quinidine or thioridazine. These medicines should not be taken together. Imipramine may increase the anti-clotting effect of warfarin. There may be an increase in side-effects such as dry mouth, constipation and blurred vision when imipramine is taken with other anticholinergic medicines e.g. hyoscine. Imipramine may increase the sedating effects of alcohol.

Other medicines containing the same active ingredients

Tofranil

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