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Fluanxol (flupentixol)

Health and Nutrition > Medicines > F

Fluanxol (flupentixol) (Contd)




Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

  • Drowsiness
  • Blurred vision
  • Increased heart rate (tachycardia)
  • Increased need to pass urine or urinary incontinence
  • Drop in blood pressure when going from lying or sitting to sitting or standing, causing dizziness and lightheadedness (postural hypotension)
  • Difficulty in sleeping (insomnia)
  • Restlessness and agitation
  • Confusion
  • Abnormal movements of the hands, legs, face, neck and tongue, eg tremor, twitching, rigidity (extrapyramidal effects)
  • Convulsions
  • Rhythmical involuntary movement of the tongue, face, mouth and jaw, which may sometimes be accompanied by involuntary movements of the arms and legs (tardive dyskinesia)
  • High blood prolactin (milk producing hormone) level - sometimes this can lead to symptoms such as breast enlargement, production of milk and stopping of menstrual periods
  • Interference with the body's temperature regulation (this is more common in elderly people and can cause heat stroke in very hot weather or hypothermia in very cold weather)
  • Weight changes
  • Sexual problems
  • Disturbances in the normal numbers of blood cells in the blood
  • Nausea
  • Dizziness
  • Headache/migraine
  • The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

    How can this medicine affect other medicines?

    It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

    There may be an increased risk of drowsiness and sedation if flupentixol is taken with any of the following (which can also cause drowsiness):

  • alcohol
  • benzodiazepines, eg diazepam, temazepam
  • strong opioid painkillers, eg morphine, codeine
  • sedating antihistamines, eg chlorphenamine, hydroxyzine
  • sleeping tablets, eg zopiclone
  • tricyclic antidepressants, eg amitriptyline.
  • This medicine may enhance the blood pressure-lowering effects of certain medicines used to treat high blood pressure (antihypertensives). If you are taking medicines for high blood pressure you should tell your doctor if you feel dizzy or faint after starting treatment with this medicine, as your blood pressure medicines may need adjusting.

    There may be an increased risk of side effects such as dry mouth, constipation, confusion or heat stroke (in hot and humid conditions) if flupentixol is taken with other medicines that can have anticholinergic effects, such as the following:

  • anticholinergic medicines for Parkinson's symptoms, eg procyclidine
  • antihistamines, eg brompheniramine, chlorphenamine
  • antispasmodic medicines, eg hyoscine, atropine
  • medicines for urinary incontinence, eg oxybutynin, flavoxate, tolterodine, propiverine, trospium
  • tricyclic antidepressants, eg amitriptyline.
  • There may be an increased risk of side effects such as tremor, movement disorders, confusion or drowsiness if flupentixol is taken in combination with lithium or sibutramine.

    There may be an increased risk of movement disorders (extrapyramidal side effects) if flupentixol is taken in combination with metoclopramide.

    Flupentixol may oppose the effects of medicines used to treat Parkinson's disease, eg levodopa.

    Other medicines containing the same active ingredient

    Depixol injection Depixol tablets
    NB. These medicines are not used to treat depression.



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