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Fareston

Health and Nutrition > Medicines > F

Health Centres - Fareston



How does it work?

Fareston tablets contain the active ingredient toremifene, which is a medicine that blocks the receptors for the female hormone oestrogen in the body. This prevents oestrogen-induced stimulation of DNA production and hence cell growth in breast cancer. Cancers form when some cells within the body multiply uncontrollably and abnormally. There are two types of cancer. Solid cancers where a lump forms e.g. the bone, breast, muscle, brain cells etc. divide and multiply abnormally. The second type are leukaemias and lymphomas where the blood cells divide and multiply abnormally. Other characteristics of cancer besides uncontrolled growth include the ability of these abnormal cells to invade other tissues next to them or to break away from the original site, travel through the blood or lymph, and establish a new cancer at a different site of the body. These are called metastases. Breast cancer can be classifed into oestrogen sensitive and oestrogen insenstitive cancers. Most breast cancer is sensitive to oestrogen. Sensitive cancer cells need oestrogen to stay alive and removal of oestrogen from the body or stopping any circulating oestrogen getting to the cancer cells can be effective at controlling or killing hormone sensitive breast cancers. Therefore, toremifene, by blocking the receptors for oestrogen will cause the cancer to shrink in size or limit the spread of the cancer to other parts of the body.

What is it used for?

- First line treatment of oestrogen-receptor dependent metastatic breast cancer

Warning!

- Any abnormal vaginal bleeding, vaginal discharge or pelvic pain and pressure should be reported to your doctor.

Use with caution in

- History of a severe problem of blood clotting
- Severe angina pectoris
- Spread of the cancer from its site of origin to bone (bone metastases). This increases the risk of hypercalcaemia (high blood calcium levels) occurring.
- Uncontrolled heart failure

Not to be used in

- Overgrowth of the lining of the womb (endometrial hyperplasia)
- Severely decreased liver function

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

- This medicine should not be used in pregnancy. Seek medical advice from your doctor.
- There is no information available about the safety of this medicine during breastfeeding. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek medical advice from your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

- Headache
- Changes in skin pigmentation
- Fatigue
- Sweating
- Weight gain
- High blood calcium level (hypercalcaemia)
- Dizziness
- Nausea and vomiting
- Abnormal vaginal bleeding
- Hot flushes
- Excessive fluid retention in the body tissues, resulting in swelling (oedema)
- Discharge of white fluid from the vagina (leukorrhoea)
- Pain

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.



The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care or attention by a qualified practitioner. The materials in this web site cannot and should not be used as a basis for diagnosis or choice of treatment. Conditions for use Powered by netdoctor
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