Edronax (reboxetine)

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The following medicines are not recommended for use in combination with this medicine, because they may prevent the breakdown of reboxetine by the liver and so increase the risk of side effects:

azole antifungals such as ketoconazole

macrolide antibiotics such as erythromycin

fluvoxamine.

Reboxetine is not recommended for use in combination with a monoamine oxidase inhibitor antidepressant (MAOI), eg phenelzine, tranylcypromine, isocarboxazid, or moclobemide. Treatment with reboxetine should not be started until at least two weeks after stopping an MAOI. Conversely, an MAOI should not be started until a week after stopping reboxetine.

There may be a risk of a rise in blood pressure if ergot derivatives, such as ergotamine or methysergide, are taken in combination with reboxetine.

The level of potassium in the blood may decrease if reboxetine is taken in combination with diuretics such as furosemide or bendroflumethiazide.

Sibutramine is not recommended for use in combination with this medicine.

Other medicines containing the same active ingredient

There are currently no other medicines available in the UK that contain reboxetine as the active ingredient.

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