DTIC-Dome

Warning!

- People taking this medicine should have regular blood tests to check the levels of their blood components.
- Your liver functioning should be monitored while you are taking this medicine. Symptoms that may suggest a liver problem include persistent nausea and vomiting, abdominal pain, or the development of jaundice (a yellow colouring to the skin and the whites of the eyes). Consult your doctor if you experience any of these symptoms.
- This medicine is vesicant, ie it can cause severe local reactions such as blistering, ulceration and death to skin and tissue should it leak out of the vein (extravasation). Great care must be taken to avoid extravasation when administering this medicine.
- Special precautions must be taken by those preparing and handling cytotoxic medicines, in order to prevent self-contamination.
- It is recommended to use effective contraception during and for at least 6 months after treatment has been administered to either men or women.

Use with caution in

- Decreased kidney function
- Decreased liver function

Not to be used in

- Allergy to any of the active ingredients
- Severe myelosuppression (reduction in blood cell production in the bone marrow)

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

- This medicine should not be used in pregnancy. Seek medical advice from your doctor.
- This medicine should not be used by breastfeeding mothers. Discuss this with your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

- Headache
- Diarrhoea
- Increased blood flow to the skin on the face (facial flushing)
- Allergic reaction to active ingredient
- Abnormal reaction of the skin to light, usually a rash (photosensitivity)
- Alteration in results of liver function tests
- Low red blood cell count (anaemia)
- Decrease in the number of white blood cells in the blood (leucopenia)
- Pain at the injection site
- Decrease in the number of platelets in the blood (thrombocytopenia)
- Serious liver damage that may very rarely be fatal
- Nausea and vomiting
- Loss of appetite
- Hair loss (alopecia)
- Cold or flu-like symptoms

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.