Diamicron (gliclazide)

How can this medicine affect other medicines?

Many medicines can affect blood sugar levels. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The following medicines may enhance the blood sugar lowering effect of this medicine and therefore increase the chance of low blood sugar (hypoglycaemia). If you start treatment with any of these your dose of this medicine may therefore need decreasing:

anticoagulants, eg warfarin (anticoagulant effect may also be altered - if you are taking an anticoagulant with this medicine your doctor may want to perform extra monitoring of your blood clotting time or blood sugar)

ACE inhibitors, eg captopril, enalapril (these can cause unpredictable drops in blood sugar)

cimetidine

disopyramide

fibrates, eg clofibrate

fluconazole

insulin

MAOI antidepressants, eg phenelzine

miconazole (should not be taken with gliclazide)

other antidiabetic tablets

phenylbutazone

large doses of salicylates, eg aspirin (small pain relieving doses do not normally have this effect)

sulphonamide antibiotics, eg sulfamethoxazole, co-trimoxazole.

Beta-blockers, eg propranolol (including eye drops containing beta-blockers) can mask some of the signs of low blood sugar, such as increased heart rate and tremor. They also prolong episodes of low blood sugar and impair recovery back to normal glucose levels.

The following medicines may increase blood glucose levels. If you start treatment with any of these your dose of this medicine may therefore need increasing:

some antipsychotic medicines, eg chlorpromazine, olanzapine

corticosteroids, eg hydrocortisone, prednisolone

danazol

diuretics, especially thiazide diuretics, eg bendroflumethiazide

oestrogens and progesterones, such as those contained in oral contraceptives.

Other medicines containing the same active ingredient

Diaglyk

Diamicron MR

Vivazide

Gliclazide tablets are also available without a brand name, ie as the generic medicine.

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