Deteclo tablets (discontinued in the UK - October 2007)

How can this medicine affect other medicines?

The absorption of tetracycline is reduced by: Quinapril (ACE inhibitor) Antacids Kaolin Calcium salts and dairy products Iron Tripotassium dicitrato-bismuthate and sucralfate (ulcer-healing drugs) Zinc salts Magnesium salts Tetracycline also reduces the absorption of iron and zinc salts. Tetracycline may reduce the effectiveness of the combined oral contraceptive pill. Tetracyclines may increase the blood thinning effects of anticoagulants such as warfarin. Tetracycline reduces the levels of atovaquone (lipid lowering drug) in the blood. If tetracyclines are taken with acitretin, isotretinoin or tretinoin there may be an increased risk of developing raised pressure within the skull (benign intracranial hypertension). Tetracyclines should be avoided in patients on diuretics as it can cause a rise in blood urea nitrogen levels. Tetracyclines may decrease the effectiveness of penicillins.

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