How does it work?

This medicine contains naproxen and misoprostol. Naproxen belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a group of chemical (prostaglandins) which the body produces in response to injury or certain diseases. These prostaglandins would otherwise go on to cause swelling, pain and inflammation. Since prostaglandins also have a role in protecting the stomach lining, a reduction in prostaglandin levels sometimes casues gastric irritation or ulceration. Misoprostol is a synthetic prostaglandin E1 analogue. It protects the lining of the stomach by mimicking the action of the naturally-occurring prostaglandins. Prostaglandins influence several factors involved in protection of the stomach lining. Misoprostol is used to promote peptic ulcer healing and relief of symptoms. Misoprostol is added to the naproxen in this medicine to prevent the formation of ulcers caused by the effects of the naproxen.

What is it used for?

A form of arthritis (ankylosing spondylitis)

Osteoarthritis

Severe inflammatory disease of the joints ( severe rheumatoid arthritis)

Warning!

People taking this medicine should have regular blood tests to check the levels of their blood components.

This medicine should not be used in women of child-bearing age unless she requires NSAID therapy and is at risk of complications from NSAID induced ulcers: in which case effective contraceptive measures should be taken.

Use with caution in

Blood clotting disorders

Children

Decreased heart function

Decreased kidney function

Decreased liver function

Disease of the blood vessels in and around the brain (cerebrovascular disease)

Inflammation of the bowel and back passage

Inflammatory bowel disease such as ulcerative colitis or Crohn's disease

Low volume of circulating blood (hypovolaemia)

Ulcer caused by a non-steroidal anti-inflammatory drug

Not to be used in

Active bleeding

Allergy to aspirin or other medicines in this class (NSAIDs), associated with a history of asthma.

Bleeding from the stomach or intestines

Bleeding in the brain (cerebral haemorrhage)

Breastfeeding

Children

Known sensitivity or allergy to any ingredient

Peptic ulcers

Pregnancy

Women of child bearing age, unless effective contraceptive measures are taken. Discuss with doctor.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should not be used in pregnancy. Seek medical advice from your doctor.

This medicine should not be used by breastfeeding mothers. Discuss this with your doctor.

Label warnings

Take this medication with or after food.

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