Co-amilozide

How can this medicine affect other medicines?

If the following are taken with this medicine they may cause a large increase in the level of potassium in the blood: - other potassium-sparing diuretics, eg spironolactone and triamterene - potassium supplements - potassium-rich food, eg potassium-containing 'low sodium' salt substitutes These should not be taken with this medicine, unless your blood potassium level is very low and your doctor can regularly monitor the level of potassium in your blood. This medicine should not be taken with the mood stabilising medicine lithium, as it reduces the ability of the body to remove lithium therefore increasing the risk of its adverse effects. If this medicine is taken with any of the following there is a risk of an increase in the level of potassium in the blood (hyperkalaemia): - ACE inhibitors, eg enalapril, captopril - angiotensin II receptor antagonists, eg losartan, valsartan - ciclosporin - tacrolimus - trilostane. If this medicine is taken with any of the following there is a risk of a decrease in the level of potassium in the blood (hypokalaemia): - corticosteroids, eg prenisolone, dexamethasone - carbenoxolone - beta-agonist bronchodilators, eg salbutamol, terbutaline. If you are taking digoxin with this medicine there is an increased risk of digoxin side effects if your blood potassium level falls. If this medicine is taken with any of the following you may have an increased risk of a drop in blood pressure, causing you to feel dizzy or faint: - other medicines for high blood pressure (antihypertensives) - narcotics - barbiturates - alcohol. Cholestyramine and colestipol decrease the absorption of this medicine from the gut, making it less effective. If you are taking either of these you should separate their dose from the dose of this medicine by as long a time as possible. Seek further advice from your doctor or pharmacist. This medicine may cause your blood glucose levels to rise. If you have diabetes you may therefore need an adjustment in the dose of your antidiabetic medicine. Discuss this with your doctor. Non-steroidal anti-inflammatory drugs (NSAIDs), such as indometacin, may decrease the effect of this medicine, and may also increase the risk of a rise in your blood potassium level and side effects on the kidneys. If you are taking an NSAID in combination with this medicine your doctor should regularly monitor your blood potassium level and kidney function.

Other medicines containing the same active ingredients

Amil-Co	Amilmaxco (discontinued in the UK)	Delvas (discontinued in the UK)
Moduret 25	Moduretic

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