Beechams all-in-one

How can this medicine affect other medicines?

If you are already taking any other medicines, including herbal medicines and those bought without a prescription, you should check with your pharmacist before taking this medicine, to ensure that the combination is safe.

You should not take other medicines that contain paracetamol in combination with this medicine, as this can easily result in exceeding the maximum recommended daily dose of paracetamol. Many cold and flu remedies and over-the-counter painkillers contain paracetamol, so be sure to check the ingredients of any other medicines before taking them with this one.

This medicine should not be used by people who are currently taking a monoamine oxidase inhibitor antidepressant, eg phenelzine, tranylcypromine, isocarboxazid or moclobemide, or who have taken one of these medicines in the last 14 days. This is because the combination of phenylephrine and an MAOI could cause a dangerous increase in blood pressure (hypertensive crisis).

If phenylephrine is taken with any of the following medicines, the combination may cause an increase in blood pressure. If you are already taking any of these medicines you should avoid taking this one as well:

beta-blockers, eg propranolol

other decongestants (often found in other non-prescription cough and cold remedies)

tricyclic antidepressants, eg amitriptyline

appetite suppressants

amphetamine-like stimulants.

Phenylephrine can reduce the effects of medicines to treat high blood pressure (antihypertensives). If you are taking medicines for high blood pressure you should not take this medicine.

Cholestyramine reduces the absorption of paracetamol from the gut. It should not be taken within an hour of taking paracetamol or the effect of the paracetamol will be reduced.

Metoclopramide and domperidone may increase the absorption of paracetamol from the gut.

Long-term or regular use of paracetamol may increase the anti-blood-clotting effect of warfarin and other anticoagulant medicines, leading to an increased risk of bleeding. This effect does not occur with occasional pain-killing doses.

Other medicines containing the same active ingredients

There are currently no other medicines available in the UK that contain this combination of active ingredients.

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