DesmoMelt (desmopressin)

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to ensure that the combination is safe.

The following medicines may increase the release of natural antidiuretic hormone in the body and may therefore increase the effect of desmopressin:

carbamazepine

chlorpromazine

non-steroidal anti-inflammatory drugs (NSAIDs), eg indometacin

SSRI antidepressants such as fluoxetine

tricyclic antidepressants such as amitriptyline.

If you are taking desmopressin with any of these medicines you should carefully follow instructions about restricting your fluid intake, because these medicines may increase the risk of fluid retention and decreased concentration of sodium in the blood.

Loperamide (used to treat diarrhoea) may increase the blood level of desmopressin taken by mouth. As a result, it may also increase the risk of fluid retention and decreased concentration of sodium in the blood. It should be avoided by people taking desmopressin tablets.

Other medicines containing the same active ingredient

DDAVP injection	DDAVP intranasal solution	DDAVP tablets
Desmospray	Desmotabs	Octim injection
Octim nasal spray

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