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Peyronie's disease

Health and Nutrition > Health Centres

Peyronie's disease (Contd)


Written by Dr John Dean, specialist in sexual medicine

What can your doctor do?

First, your doctor should be able to reassure you that you do not have cancer.

Drug treatment This is a controversial area, as only limited evidence of the effectiveness of drug treatment exists. However, such treatment is worth considering in men with early or active Peyronie's disease, that is when the lump is expanding or is painful. The aim is to reduce pain, lump size and the eventual deformity.

  • Vitamin E and potassium aminobenzoate: these drugs have been shown to improve pain in 30 to 60 per cent of affected men, but do not seem to affect lump size or deformity of the erect penis.
  • Tamoxifen: one study demonstrated that tamoxifen not only improved pain in about 80 per cent of affected men, but reduced lump size and deformity in about 30 per cent of men. The study was in men with early disease and soft plaques. No evidence exists of benefit in men with long-established disease. Tamoxifen is usually used in the treatment of breast cancer, but has relatively few side effects. Although not licensed for use in Peyronie's disease, some specialists will recommend it.
  • Steroid injections: several studies have looked at injecting steroids into Peyronie's plaques in an attempt to reduce pain, deformity and lump size, but the results have been very disappointing.
  • Verapamil injections: one study in a very small group of men has shown that repeated injections of verapamil into the Peyronie's plaque improved pain, deformity and lump size. Given that penile injection is a potential cause of Peyronie's disease, more evidence from larger, long-term studies must be gathered before this can be recommended as a treatment.

    • Extracorporeal shockwave therapy

    Studies in the UK and Germany have shown that extracorporeal (outside the body) shockwaves directed at Peyronie's plaques can reduce penile deformity in established, stable disease.

    This technique has been used to smash kidney and gallstones for many years, and might avoid the need for surgery in established Peyronie's disease. Treatment is given over several sessions on an outpatient basis. This technique is still under investigation and is not yet widely available.

    Surgery

    Because the development of Peyronie's disease varies so much between individuals, a wise strategy is to adopt a conservative approach to treatment and avoid early surgical intervention. Surgery should be done only to correct penile deformity in men with stable Peyronie's disease that has been present for at least a year and has not changed whatsoever for at least three months.

    It is essential that the disease has stabilised and become inactive before surgery is attempted, otherwise the condition can continue to progress after the operation has been performed.

    The indications for surgery are:

  • unacceptable difficulty with penetration during sex
  • pain during sex for either partner that is a consequence of the penile deformity.

    • Unacceptable cosmetic appearance of the erect penis is not a good reason to have surgery unless it is causing severe and intractable psychological distress.

    Success of surgery is usually measured by the correction of deformity but there are no guarantees that the penis will be perfectly straight after surgery. In addition, some men will develop erectile dysfunction or even numbness of the penis following surgery, so it is not a treatment to contemplate without considerable caution.

    Types of surgery

    Plaque excision and grafting Simply cutting out the plaque from the tunica albuginea and filling the defect with a skin graft from the abdominal wall seems to be a logical way of treating Peyronie's disease. However, results are disappointing, with success rates from studies reported between 20 and 70 per cent. Worse still, between 16 and 70 per cent of men suffer erectile dysfunction after surgery.

    Plaque incision and grafting

    Incising (cutting through) the plaque, either with a scalpel or laser, and then filling the defect with a graft has the advantage of preserving the tunica and maintaining penile length. Although results from studies seem better than for plaque excision, the research only involved a very small number of men and more work is need to confirm its safety and effectiveness.

    Corporoplasty

  • Plication of the corpora: plication of the corpus cavernosum (in simple terms, stitching a small tuck into the corpus) on the opposite side to the plaque may improve deformity but will shorten the erect penis. Success rates of 50 to 60 per cent have been reported with this technique.
  • Nesbit's operation: this operation involves removing a section of corpus cavernosum on the opposite side to the plaque, then suturing the edges together. This corrects the deformity but, again, will result in penile shortening. Success rates of up to 80 per cent have been reported with this technique.

    • In both of these procedures, circumcision will also normally be performed, as foreskin problems frequently follow these operations in uncircumcised men.

    Prognosis

    Peyronie's disease runs a very variable course. Many men with Peyronie's disease will not require or desire treatment, and will enjoy very satisfactory sex with their rather unusually shaped penis

    Men who have had Peyronie's disease are more likely to have a further episode in the future than the general population. Nothing is proven to prevent a recurrence.



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    The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care or attention by a qualified practitioner. The materials in this web site cannot and should not be used as a basis for diagnosis or choice of treatment. Conditions for use

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