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Depression is likely to be one of the greatest, if not the greatest, disease burdens of the 21st century. It is a very common condition that causes a great deal of suffering and a substantial number of deaths. Depression leads to disharmony at home, difficulties at work and internal distress. Unfortunately, the condition still attracts much stigma, is not always recognised and, when recognised, is not always adequately treated. Depression is more common in women than in men, though its most dramatic outcome, death by suicide, is more common in men.
How is depression diagnosed?
The diagnosis of depression is made when several core features are present:
Other features can also be present, including:
Depression is often more difficult to diagnose in men because they do not complain of these typical symptoms so often. They are less likely to admit to distress and if they do consult their doctor, tend to focus on physical complaints.
How common is depression?
In community surveys, 2 per cent of the population suffer from pure depression at any one time. Some have a mild form of the illness, some moderate and some severe, in roughly equal numbers. Another 8 per cent of the population suffer from a mixture of anxiety and depression at any one time. Other people do not have symptoms severe enough to qualify for a diagnosis of either anxiety or depression but have impaired working and social lives and unexplained physical symptoms.
The lifetime rate of depression is 8 per cent for men and 12 per cent for women, and these figures seem to be rising. This trend is worrying and has been much discussed. Depression is now more frequently diagnosed in younger people than it was previously. This change could well be a result of the increasing social fragmentation, including family breakdown, seen over recent decades.
How is depression treated?
Mild episodes of depression often get better without treatment or will respond to simple measures such as changes in the social environment or the family situation. Many other patients can be treated adequately by their GP. Only a minority of patients ought to be referred to specialist psychiatric services.
Patients who should be referred include those:
If depression co-exists with other conditions that complicate treatment, such as a physical illness, patients should usually be referred to a specialist. Patients with a psychotic depression, who are troubled by delusions (abnormal beliefs) or hallucinations, should always be referred.
Antidepressant medication
Approximately half of all patients with depression only ever have one episode. The others suffer from a recurrent form of the illness. Taking this into consideration, the doctor might think it wise to prescribe maintenance treatment, which means continuing antidepressants for a number of years to prevent further episodes.
The art of treatment is to combine social, psychological and pharmacological approaches to reduce suffering and mortality. The advent of the new antidepressants and the increasing evidence that certain forms of counselling (problem-solving and cognitive-behavioural therapies) do work means that we can be optimistic about the future for people with depression. However, depression becomes chronic in 10-20 per cent of cases.
Psychotic depression
Suicide and men
The higher suicide rate among men is a worldwide phenomenon. A few exceptions to the general rule exist, for example, among elderly women in Hungary and in some Asian countries. The reasons why men are more likely to kill themselves than women are complex and ill-understood. However, several pointers help our understanding.
Since the late 1950s, effective medication has been available for depressive illness. In recent years, new antidepressants, with fewer side effects, have become available. These are effective for most people and relatively easy to tolerate. Whichever antidepressant is used, it is important to continue treatment for six to nine months after symptoms resolve otherwise symptoms might return quickly. Antidepressants are equally effective in men and women.
Patients with psychotic depression are seriously ill and will almost always require hospitalisation. Antidepressant therapy alone is unlikely to be effective. The treatments of choice are either electroconvulsive therapy (a highly effective but controversial treatment that involves passing electricity through the brain under general anaesthetic) or a combination of an antidepressant with an antipsychotic medicine (a type of medication that treats delusions and hallucinations).
Suicide accounts for l in 100 deaths but the majority of those are men. A worrying recent trend is the increasing rate of suicide among younger men (a trend not seen among young women). The majority of these men have not asked for help before their deaths. The suicide rate in men also increases in those aged between 65 and 75 years. In contrast, the suicide rate in women varies less with age.
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