From: www.tiscali.co.uk/lifestyle/
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What are fertility problems?
Infertility can be defined as the failure to achieve pregnancy after regular unprotected sex (without the use of any contraception) for at least a year. 'Primary' infertility means failure to achieve a first pregnancy, 'secondary' infertility means failure to achieve a subsequent pregnancy.
Primary infertility is an extremely common problem, affecting more than one in seven (15 per cent) couples attempting their first pregnancy. Among those experiencing difficulty with conception, a male fertility problem is considered important in around 40 per cent of couples. In 15 per cent of couples it will be solely a male fertility problem and in around 25 per cent, there will be a problem in both partners.
Why do men get fertility problems?
There are several causes of fertility problems in men. They
include:
Obstructive problems
A blockage in a sperm-carrying tubes has many potential causes.
The most common are outlined below.
Some men have congenital (present at birth) absence of the vas deferens on one or both sides. The vas deferens is the tube that conducts the testicular component of semen to the urethra, which then carries semen through the penis to the outside world. About 10 per cent of men with an obstructive cause for their infertility will have this problem. The seminal vesicles (where other semen components are made) are often absent too.
Another rare obstructive cause is Berry-Perkins-Young syndrome, in which sufferers have a chronic chest disease (bronchiectasis), chronic sinusitis and obstructive infertility.
Testicular injury and disease
A blow to the testicles, which may occur in sport or during a
fight, can cause swelling of the testicles, or bleeding in or around them. This
probably causes the blood supply to the testicles to fail, resulting in
permanent damage to the sperm production mechanism. Torsion of the testicles
(twisting of a testicle on its cord) can have a similar effect if it is not
treated very quickly with surgery. Viral infections can cause inflammation of
the testicles (orchitis, which usually appears as painful swelling of the
testicles) and failure of sperm production.
Mumps is the best-known cause, but is not the only one. Mumps will only affect fertility if it causes orchitis and, even then, only rarely. Undescended testicles (cryptorchidism) are another common cause of failure of sperm production. Male infants and children are routinely examined to identify this problem, as future fertility can only be preserved if surgical treatment to fix the testicles in the scrotum is performed in early childhood. Even surgery in infancy does not guarantee future fertility.
Varicocele
A varicocele is a dilation of the testicular veins in the
spermatic cord that leads from the testicles to the abdomen. The role of this
condition in causing infertility is uncertain and highly controversial.
Varicoceles occur in 15-20 per cent of fertile men and 30-40 per cent of men
with fertility problems. They can occur on either or both sides, but are far
more common on the left.
They are best identified when the man is standing up and are often described as feeling like 'a bag of worms'. Experts suggest that the varicocele either heats up the testicles or impairs their blood supply resulting in a build-up of body waste products, thus affecting fertility. The co-existence of other risk factors, such as smoking, with varicocele seems to have a greater effect on the risk of infertility.
Sperm disorders
Disorders of sperm numbers, movement and shape are common in men
with infertility. Prolonged abstinence from ejaculation can affect sperm
motility. Modern techniques can identify structural and biochemical
abnormalities within the individual sperm.
Genetic disorders
Problems with chromosomes (packages of genetic material) occur
in about 2 to 20 per cent of infertile men and can affect their fertility in
two ways:
Problems with erection and ejaculation
Problems with sex are the principal cause of infertility in
about 5% of couples. This can be due to:
Hormonal problems
Testosterone deficiency can reduce fertility and may be caused
by problems with testicular testosterone production, or problems with the
pituitary gland or hypothalamus in the brain, which control testosterone
production. Overproduction of prolactin (hyperprolactinaemia), a hormone
produced by the pituitary gland, may also reduce fertility.
General medical disorders that reduce fertility
There are several conditions that may reduce
fertility:
Drugs that reduce fertility
Many drugs, both prescribed and those used recreationally, can
reduce fertility. Any fertility concerns related to prescribed drugs should be
discussed with your GP - do not just stop taking them yourself.
| Recreational drugs | Effect |
| Alcohol | Reduces sperm count and quality |
| Tobacco | May reduce sperm motility |
| Marijuana | May affect hormone production |
| Opiates (heroin, morphine) | Affect hormone production |
| Anabolic steriods | Affect hormone production |
| Prescribed drugs | Effect | Main Use |
| Amiodarone | Inflammation of the testicles and epididymis (epididymo-orchitis) leading to problems with sperm production | Abnormal heart rhythm |
| Cancer chemotherapies | May severely reduce sperm count, quality and motility. Effects may bepermanent | Cancer |
| Cimetidine | Affects hormone production and reduces sperm count | Peptic ulcer and acid reflux disease, indigestion |
| Colchicine | May severely reduce sperm count | Gout |
| Digoxin | Affects hormone production | Heart failure; abnormal heart rhythm |
| Erythromycin | May reduce sperm count | Chest infections |
| Gentamicin | Reduces sperm count | Bacterial infections |
| Hormonal therapies | May disrupt other hormone production | Various |
| Ketoconazole | Reduces sperm count | Fungal infections |
| Methotrexate | Reduces sperm count | Some cancers; arthritis |
| Nitrofurantoin | Reduces sperm count | Urinary tract infection |
| Phenytoin | Reduces sperm quality and motility | Epilepsy |
| Spironolactone | Affects hormone production | Fluid retention |
| Sulphasalazine | Reduces sperm count and quality | Ulcerative colitis |
Several media reports have highlighted research studies showing that sperm counts are falling and that male fertility is declining, possibly because of environmental pollution. A similar number of studies have shown no change whatsoever, but these do not make such good headlines and often fail to be reported in the media.
Is male fertility in decline? Because evidence exists both one way and the other, the answer must be 'maybe'! One thing is certain, and that is that many more environmental toxins that might affect fertility exist now than 50 years ago.
| Potential toxin | Origin | Effect |
| Alkylphenols | Industrial and domestic detergents | Hormonal disrupter |
| Bisphenol A | Lacquers to coat foods; dental treatments | Hormonal disrupter |
| Dioxins | Paper production; transformer disposal | Hormonal disrupter |
| Organochlorine pesticides (Lindane, DDT, etc,) | Lindane used on cereals, soft fruits, cabbage | Hormonal disrupter |
| Phthalates | Plastics industry | Hormonal disrupter, testicular toxin |
| Phyto-oestrogens (found in certain types of plant products) | Some soya products | Hormonal disrupter |
| Vinclozolin | Fungicide used on foods | Hormonal disrupter |
Although fertility is affected by many factors, particular a woman's age, the chance of a young couple conceiving following regular intercourse is about one in five (20 per cent) in each menstrual cycle. The odds remain the same in each cycle and you are not guaranteed conception after five menstrual cycles. However, most couples can expect to conceive within six months.
Do not be too concerned if you fail to conceive after only two or three of your partner's menstrual cycles, even if friends seem to conceive straight away.
Although it is affected by many factors, particular a woman's age, the chance of a young couple conceiving following regular intercourse is about one in five (20 per cent) in each menstrual cycle. The odds remain the same in each cycle and, although it might sound likely, a couple are not guaranteed conception after five menstrual cycles. However, most couples can expect to conceive within six months.
Seeking some initial advice after six months or so is reasonable and you should not feel that you must wait for a year. Most doctors are very understanding and may not insist on a year's failure to conceive, just in order to fulfill an arbitrary medical definition.
How are the causes of fertility problems diagnosed?
The first place to seek advice regarding a conception problem is
your GP. You and your partner should be assessed as a couple, at the same time,
rather than one after the other. It is very important not to attach blame to
yourself or your partner, even if one of you has an obvious problem.
Both of you are reasonably likely to contribute problems that affect your chance of conception. Trying to conceive and undergoing medical assessment is stressful enough without putting additional strain on your relationship through mutual antagonism.
What else could it be?
n some couples, no cause can be found for their failure to
conceive, despite very intensive investigation. Both partners seem quite
healthy, but they simply do not conceive together. This can be very distressing
and seem quite incomprehensible, but it does happen reasonably
frequently.
Self-help
There are a number of things that men can do to help preserve
and promote their fertility.
Two other actions have been suggested. They may improve sperm quality parameters, but evidence that they improve the successful pregnancy rate is poor or non-existent.
What can your doctor do?
Your GP should be able to identify many of the common causes of
male fertility problems, or refer you to a fertility specialist (usually a
urologist, gynaecologist or specialist in reproductive medicine) for advice.
Surgery, including vasectomy reversal, may be helpful for some men with
obstructive problems.
However, success is not guaranteed, and assisted conception techniques, including in-vitro fertilisation ('test-tube' babies or IVF), may offer a better chance of a pregnancy.
Although assessment and initial investigation is available within the NHS, vasectomy reversal, assisted conception and some other fertility treatments are either not available or have very limited availability in most health districts. Private treatment may cost several thousand pounds, again with no guarantee of success.
Prognosis
Sadly, most disorders affecting sperm quality and production
either cannot be cured or do not respond well to treatment. However, assisted
conception techniques, including use of donated sperm, can help affected
couples achieve a successful pregnancy, even if there are very severe sperm
production problems.
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care or attention by a qualified practitioner. The materials in this web site cannot and should not be used as a basis for diagnosis or choice of treatment. Conditions for use
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